Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients

VernacularTitle:二肽基肽酶-6基因多态和散发性肌萎缩侧索硬化发病风险的相关性
Author: Xiaoguang LI ; Jianghu ZHANG ; Liying CUI ; Mingsheng LIU ; Manqing XIE ; Benhong LI ; Yanhuan ZHAO ; Haitao REN
Publication Type:Journal Article
Keywords: Amyotrophic lateral sclerosis; Nerve tissue proteins; Peptide hydrolases; Potassium channels; Polymorphism,single nucleotide; China
From: Chinese Journal of Neurology 2009;42(5):332-335
CountryChina
Language:Chinese
Abstract: Objective To investigate whether the polymorphism of rs10260404 in DPP6 gene in Chinese Han origin is associated with sporadic amyotrophic lateral sclerosis (SALS). Methods The genomic DNA was extracted from the leukocytes of whole blood samples in 58 Chinese Han patients with SALS and 52 healthy controls. The asymmetric PCR was processed in the presence of an unlabeled probe that contained the rs10260404 locus. The product was genotyped on light scanner and some was confirmed with sequencing. Results Two single nucleotide polymorphism, rs10260404 that was reportedly consistently strongly associated with susceptibility to SALS in different populations of European and American ancestry, rs10260404 were genotyped, but not strongly associated with ALS in Chinese patients(SALS:C:12.94%,T:87.06%;health controls:C:10.58%,T:89.43%;χ2=0.29,OR=1.256,95%CI 0.549-2.872, P>0.05). Conclusion The rs10260404 is not associated with ALS susceptibility in Chinese people.