Study on the connection between adiponectin and chronic hepatitis B associated with liver fibrosis
10.3760/cma.j.issn.1673-4904.2009.13.010
- VernacularTitle:脂联素与慢性乙型肝炎肝纤维化的关系研究
- Author:
Jinxian LIU
;
Jindong FU
;
Hui WANG
;
Xuefeng LU
- Publication Type:Journal Article
- Keywords:
Hepatitis B,ehronie;
Liver cirrhosis;
Lamivudine;
Adiponectin
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(13):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the adiponectin expression in the chronic hepatitis B (CHB) patients and compare the level of edipanectin before and after antiviral therapy, and investigate the relationship between ediponectin and CHB. Methods Serum adiponectin was detected by enzyme linked immunosorbent assay (ELISA), and the expression of adipanectin in liver tissue was detected by palymerase chain reaction (PCR) and immunohistochemistry. The liver functions and HBV DNA were also tested. Liver biopsy tissue was assessed by fibrosis stage. Results Serum adipanectin in CHB liver cirrhosis [(20.65 ± 1.29) mg/L]was higher than that in other stage fibrosis, the values were (8.57 ± 0.28 ), (12.22 ± 0.64), (15.22 ± 0.77 ) mg/L (P< 0.01 ). Serum adiponectin was positively associated with fibrosis stage(r = 0.976,P< 0.01 ). There was no significant difference between HBV DNA and ALT (P> 0.05 ). Serum adipanectiu was independently associated with liver cirrhosis (r = 1.07, P = 0.02, 95% CI = 1.00-l.14).At the end of antiviral therapy,the expressions of adiponectin declined in patients with improved fibrosis and sustained viral response. Conclusion Serum adiponectin may play a role in CHB fibrosis, and reduced adipanectin level is associated with improved fibrosis after antivital therapy.
