Relationship between methylenetetrahydrofolate reductase gene polymorphism and unstable angina pectoris disease

VernacularTitle:四氢叶酸还原酶基因多态性与不稳定型心绞痛关系的研究
Author: Hui YE ; Qiankun YE ; Gaixia DONG ; Xiangjing ZHOU ; Geng TIAN ; Ying LI ; Yaohui HUANG
Publication Type:Journal Article
Keywords: Unstable angina pectoris; Methylenetetrahydrofolate reductase; Gene; Polymorphism
From: Clinical Medicine of China 2009;25(5):480-482
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between methylenetetra hydrofolate reduetase (MTHFR) C677T genotypo and unstable angina pectoris(UA) in Chinese population. Methods The study consisted of 90 UA cases (UA group), and an age- and sex- matched healthy control cases (control group, n = 90). PC R-RFLP was used to analyze polymorphism of the MTHFR C677T genotypo. The relationship between MTHFR C677T genotype and UA was observed. Results MTHFR 677C→T mutation was found in 30 of 90 patients with unstable angina pectoris (33.33%) and in 15 of 90 control subjects (16.67%). This difference was statistically significant (P<0.05). Conclusion MTHFR 677C→T mutation is closely related to the unstable angina poctoris.