Effects of rosuvastatin on endothdial function during myocardial ischemia-reperfusion injury in rabbits
10.3760/cma.j.issn.1671-0282.2009.05.016
- VernacularTitle:瑞舒伐他汀对兔心肌缺血-再灌注损伤内皮功能的影响
- Author:
Jianqun MA
;
Lei ZHANG
;
Lianwen WANG
;
Yuqun ZHU
;
Changyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Rosuvastatin;
Myocardial ischemia-reperfusion injury;
Nitric oxide;
Endothelia-1;
Rabbit
- From:
Chinese Journal of Emergency Medicine
2009;18(5):508-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of endothelial function during myocardial ischemia-reperfusion injury in rabbits and the effect of Rasuvastatin. Method Sixteen New Zealand rabbits were randomLy divided into two groups: ischemia/reporfusian injury group (control group) and Resuvastatin group(drug group). The myocar-dial ischemia-reperfusion model was established by occlusion of left anterior descending coronary artery for 40 min-utes evidenced by the elevation of the ST segment≥0.2 my on ECG waveform, and after release of ooclusion, the ST segment of ECG retttmed to 1/2 or more of the normal wavefonn, which was the evidence of successful reperfu-sion. The rabbit serum nitric oxide (NO) and plasma endothelia-1 (ET-1) content were assayed before occlusion, 40 minutes, 60 minutes and 180 minutes after reperfusion. SPSS11.5 software was used for ANOVA(Repested Measurement designs). P<0.05 was considered as statistically significant. Results There were no significant differences in serum NO and plasma ET-1 between two groups bsfore isehemia, but 40 minutes, 60 minutes and 180 minutes after reperfusion, the levels of serum NO in drug group were higher than those in control group [(82.000±13.825), (63.375±17.541), (50.250±18.987)μmol/L vs. (63.125±18.962), (43.500± 16.518), (29.625±14.162) μmol/L, P<0.05], and the levels of plasma ET-1 content in drug group were lower than those in the control group [(282.541±38.928), (315.152±55.263), (377.795±60.427) pg/mL vs. (331.785±35.341),(375.914±5.204),(459.829±70.110) pg/mL, P<0.05]. Conclusions By the means of increasing serum NO and decreasing plasma ET-1, rosuvastatin can improve the endothelial function in rabbits with isehemia-reperfusion injury.
