Safety and efficacy of Tirofiban in patients with acute coronary syndrome

VernacularTitle:盐酸替罗非班对急性冠状动脉综合征患者的疗效观察
Author: Bin YUAN ; Shenghu HE ; Jing ZHANG ; Jianfeng YAN ; Shu CHEN ; Yong XIE
Publication Type:Journal Article
Keywords: Acute coronary syndromes; Therapy
From: Chinese Journal of General Practitioners 2009;8(5):334-337
CountryChina
Language:Chinese
Abstract: A total of 159 patients with acute coronary syndrome(ACS)were enrolled from December 2006 to June 2008 and divided into the percutaneous coronary intervention(PCI)group and the internal medicine treatment group.The participants in the two groups were further assigned to the Tirofiban or the placebo control group.The change in electrocardiograph within 48 hours,major adverse cardiac events (MACE)during hospital stay and 30 days' follow-up,and bleeding were compared between the sub-groups.As a result,in comparison with the placebo control groups,the Tirofiban sub-groups showed significant improvement in electrocardiography(P＜0.01).In the internal medicine treatment group,the rate of MACE during 30 days' follow-up was significantly decreased in patients treated with Tirofiban(P＜0.05),although no significant difference in bleeding rate was found.Our data suggest that Tirofiban may be safe and effective in the treatment of ACS.