Peripheral benzodiazepine receptors and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2009.04.009
- VernacularTitle:外周型苯二氮革受体与脑缺血
- Author:
Chao CHENG
;
Chunfu CHEN
- Publication Type:Journal Article
- Keywords:
receptors,GABA-A;
cerebral ischemia;
microglia;
neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2009;17(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
1he increased peripheral benzodiazepine receptors are more significant than normal ones after cerebral ischemia. Its main reactions are the multiple pathological changes,including microglial activation, participating in neuroinflammation response, and regulation of mitochondrial function. Using radionuclide-laheled specific ligands of the peripheral benzodiaz-epine receptor (such as PK11195) for in vivo imaging contribute to the location and quantitative detection for brain injury and the study of the pathophysiological changes after cerebral ischemi-a. In addition, this receptor is promising to become a new target of neuroprotective treatment.This article reviews the recent progress in research on peripheral benzodiazepine receptors and cerebral ischemia.
