Association analysis of CD22 polymorphism with the development of systemic lupus erythematosus in Southern Chinese Han people
10.3760/cma.j.issn.1007-7480.2009.05.005
- VernacularTitle:CD22基因多态性与中国南方汉族人群系统性红斑狼疮相关性研究
- Author:
Yuanyuan QI
;
Hui PENG
;
Xiaohui YANG
;
Lingjie KONG
;
Shuna GAO
;
Feng JIANG
;
Chaowei FU
;
Xiuzhen YU
;
Baotao WANG
;
Aie XU
;
Wei MENG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Receptors,interleukin-2;
Polymorphism,single nucleotide
- From:
Chinese Journal of Rheumatology
2009;13(5):301-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of CD22 gene T＞A locus (SNPrs2267574) with the development of systemic lupus erythematosus (SLE) and SLE phenotypes in Southern Chinese Han people.Methods Two hundreds fifteen cases and 216 normal controls were enrolled with the aim of case-control design,and the genotype was determined by PCR-RFLP.We calculated X2 and ORs for association study.Results In CD22 gene T＞A locus,there was significant difference of genotypes distribution between cases and controls (X2=6.086,P＜0.05).The frequency of AT genotype was higher in cases than in controls (OR=1.68,95%CI:1.08～2.60,P=0.021 ),and A allele had a higher proportion in cases (OR=1.58,95%CI:1.09～2.29,P=0.015).Meanwhile,the frequency of A allele in patients with positive anti-SSA was higher than in patients with negative anti-SSA (OR=3.69,95%CI:2.08～6.52,P＜0.01 ).Conclusion In Southern Chinese Han population,CD22 gene T＞A locus is associated with the development of SLE and the A allele has positive association with anti-SSA.
