Dynamic changes of thyroid function in patients with post-stroke depression and its clinical significance
10.3760/cma.j.issn.1674-6554.2009.02.009
- VernacularTitle:脑卒中后抑郁患者甲状腺功能动态变化及临床意义
- Author:
Chunxia WANG
;
Jing CHEN
;
Renliang ZHAO
- Publication Type:Journal Article
- Keywords:
Post-stroke depression(PSD);
Depression;
Thyroid function
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2009;18(2):120-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significances of thyroid function changes in patients with post-stroke depression(PSD). Methods Sixty two cases with acute cerebral infarction (CI) were stratified into two groups by Zung self-rating depression scale, single cerebral infarct patients group (CI group) and PSD group. Serum levels of FT3, FT4 and TSH of the patients were detected on 2 days,7days,14 days and 21days after admission. Results ①On each time point after admission, FT3 levels in PSD group were lower than those in CI group. FT3 levels in the two groups on the 7 days were higher than those on 2 days(2.04±0.53 vs 1.28±0.19, 1.43±0.91 vs 1.07±0.37, P <0.05).On the 14 and 21 days, levels of FT3 in the PSD group were continuously increased.②On the 2 days and 7 days after admission, FT4 levels in PSD group were higher than those in CI group. FT4 levels in the two groups on the 14 days were lower than those on 7 days(1.52±0.18 vs 2.09±0.26, 1.57±0.31 vs 2.28±0.38, P <0.05). ③On the 2 days after admission,the TSH level in the PSD group were lower than that in CI group(2.02±0.36 vs 2.27±0.49,P <0.05). Conclusion The results indicated that the hypothalamic-pituitary-thyroid axis plays important role in the pathogenesis of PSD.
