Effect of the Donglian Capsule on Early Insulin Resistance in Experimental Diabetic Rats

VernacularTitle:冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响
Author: Rui WANG ; Pu GAO ; Jiangang UU
Publication Type:Journal Article
Keywords: Donglian Capsule. Diabetic insulin Resistance; Pancreas Glucagon
From: International Journal of Traditional Chinese Medicine 2009;31(3):203-204
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.