Effect of trimetazidine dihydrochloride on the serum levels of IL-18 and TNF-α in children with viral myocardiris

VernacularTitle:曲美他嗪对儿童病毒性心肌炎患者血清IL-18和TNF-α的影响
Author: Ruiqing ZHAO
Publication Type:Journal Article
Keywords: Myacarditis; Viruses; Interleukin-18; Tumor necrosis factor-alpha; Trimetazidine; Child
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(4):608-609
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects and mechanism of trimetazidine dihydrochloride on children with viral myocarditis(VMC). Methods 102 patients with VMC were randomly divided into two groups:patients in control group(n=44) received routine therapy,and patients in treatment group(n=58) received trimetazidine dihy-drockloride with routine therapy for three months. Serum levels of interleukin-18 (IL-18) and tumor necrosis factor (TNF-α) were measured pre- and post- therapy. Results Compared with control group,the serum levels of IL-18 and TNF-α was decreased following trimetazicline dihydrechlofide therapy(P<0.05). Conclusion Trimetazidine di-hydrochloride could retard progression in VMC patients which was achieved through improving serum levels of IL-18 and TNF-α.