Relationship between glucose fluctuation state and diabetic chronic complications in type 2 diabete mellitus
10.3760/cma.j.issn.1008-6706.2009.04.013
- VernacularTitle:波动性高血糖状态与糖尿病血管病变的关系
- Author:
Xiaozheng FANG
;
Min CHEN
;
Manyun ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,Type 2;
Diabetic Angiopathies;
Blood geucose
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(4):599-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation between glucose fluctuation state and diabetic chronic compli-cations in type 2 diabetes mellitus. Methods 169 cases with type 2 diabetes mellitus were divided into two groups: 78 cases with constant high glucose(group Ⅰ) and 91 cases with glucose fluctuation state( group Ⅱ ). The clinical data such as fasting plasma glucose(FBG) ,fasting blood insulin(FINS) ,fasting blood C peptide,2 hours postprandial plasma glucose (2hPG) ,2 hours postprandial blood insuline (2hINS) ,2 hours postprandial blood C peptide, glycosy-lated hemoglobin A1c (HbA1c), and blood pressure (BP), body mass index ( BMI ), urinary albumin excretion rote (UAER) ,triglyeeride(TG) ,total cholesterol(TC) ,high density lipoprotein cholesterol(HDL-C) ,low density lipopro-tein cholesterol(LDL-C) were measured. Results 2hPG in group Ⅱ was much higher than that in group Ⅰ (P<0.01) ,but 2 hours postprandial blood insuline and 2 hours postprandial blood C peptide in group Ⅱ were much lower than those in group Ⅰ (P<0.01). The incidence of diabetic chronic complications was higher in group Ⅱ compared with that in group Ⅰ (P<0.01). Conclusion These findings suggest that glucose fluctuation state with type 2 dia-betes mellitus had increased diabetic chronic complications.
