Gene polymorphisms association studies in sepsis
10.3760/cma.j.issn.1673-4203.2009.05.014
- VernacularTitle:脓毒症的基因多态性研究
- Author:
Yu FANG
;
Lei LI
;
Baochi LIU
;
Gangqiao ZHOU
- Publication Type:Journal Article
- Keywords:
sepsis;
polymorphism;
genetic association;
susceptibility
- From:
International Journal of Surgery
2009;36(5):325-328
- CountryChina
- Language:Chinese
-
Abstract:
Although significant advances have been made in both the development of therapeutic strate-gies and the understanding of pathophysiological mechanisms of sepsis, the mortality of severe sepsis and septic shock still remains unacceptably high worldwide. Current prediction models based on socio-demo-graphic and clinical risk factors fail to explain fully why a particular patient either develops or succumbs to sepsis. In recent years epidemiological studies have suggested a strong genetic relationship on the suscepti-bility and outcome of sepsis. With the completion of Human Genome Project and International HapMap Pro-ject, the identification of susceptibal genes contributing to sepsis may allow more precise use of interven-tions, such as targeted therapy of sepsis is an appealing strategy. In this review, we summarize a broad over-view of genetic nomenclature, study designs, and problems of these genetic association studies.
