Akt/PKB signaling pathway and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2009.02.015
- VernacularTitle:Akt/PKB信号转导通路与脑缺血
- Author:
Lixuan ZHAN
;
En XU
- Publication Type:Journal Article
- Keywords:
protein-serine-threonine kinases;
protein-tyrosine kinases;
cerebral ischemia;
ischemic preconditioning
- From:
International Journal of Cerebrovascular Diseases
2009;17(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
After being activated by the growth factor-mediated receptor tyrosine kinase phosphorylation, Akt activates a series of substrate molecules, including Forkhead transcription factors etc, which regulate cell survival and death. With the changes of Akt phosphorylation levels (Ser473) after cerebral ischemia, its upstream and downstream protein phosphorylation levels have also changed. Preconditioning may produce ischemic tolerance by changing the levels of Akt protein phosphoryiation. Dysfunction of Akt/PKB signal transduction pathway may mediated neuronal death after cerebral ischemia.
