mRNA expression of neuroglobin in thalamus of DAI rats
- VernacularTitle:大鼠弥漫性轴索损伤后丘脑NGB mRNA的表达
- Author:
Zhenyan LI
;
Guangwei ZHONG
;
Junyu WANG
;
Yunsheng LIU
;
Sue WANG
;
Wei LI
;
Zhixiong LIU
- Publication Type:Journal Article
- Keywords:
Diffuse axonal injury/ME;
Nerve tissue proteins/BI;
Thalamus/ME
- From:
Journal of Chinese Physician
2009;11(4):436-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study mRNA expression of neuroglobin (NGB) in thalamus of DAI rats and explore the relation between NGB and heed injury. Method 46 male SD rats were randomly divided into four groups. The DAI model was established according to modi-fied Mamamu method. The mRNA expression of NGB in thalamus at different time point after injury was detected by RT-PCR method. All data were analyzed with statistical software. Result The mRNA expression of NGB in thalamus increased obviously from 30 minutes after in-jury while decreased at the 24th hour after injury. But the expression increased again and reached peak at the 48th hour after injury. Conclu-sion The mRNA expression of NGB in thalamus increased after DM. Those changes suggested NGB might participate in the response mech-anism of stress, secondary ischemia and hypoxic brain injury after neuron injury.
