Expression of CD4+, CD25+ regulatory T cells and its significance in carcinoma of stomach
- VernacularTitle:胃癌组织中CD4+、CD25+调节性T淋巴细胞的表达及意义
- Author:
Lin TIAN
;
Minna LIU
;
Lihua HU
;
Xueying CHEN
;
Yu CAI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/IM;
CD4-positive T-lymphocytes;
Receptors,interleukin-2;
T-lymphocytes
- From:
Journal of Chinese Physician
2009;11(4):439-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of CD4+, CD25+ regulatory T cells and its significance in carcinoma of stomach. Methods Flow cytometry was used to quantify and analyze the results of CD4+, CD25 + regulatory T cells and CD8+ T cells in 76 patients with gastric cancer. Results CD4+, CD25+ regulatory T cells expression in gastric cancer tissue, adjacent tissues and control group are (1.2±0.9) %, (6.4±1.1) % and (4.1±0.8) %. The results have statistical significance (P<0.05). CD8+ T cells markedly de-creased in gastric cancer tissue, while CD4+ , CD25+ regulatory T cells increased. But this manifest did not happen in adjacent tissues.Conclusion CD4+, CD25+ regulatory T cells suppress gastric cancer though inhibiting CD8+ T cells.
