Pre-and post-operative chemotherapy for hepatic metastases from resectable colorectal cancer
10.3760/cma.j.issn.1673-422X.2009.04.023
- VernacularTitle:可切除结直肠癌肝转移患者的术前和术后化疗
- Author:
Rongbo LIN
;
Nanfeng FAN
;
Ling CHEN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Liver;
Neoplasms metastasis;
Adjuvant,chemotherapy
- From:
Journal of International Oncology
2009;36(4):306-308
- CountryChina
- Language:Chinese
-
Abstract:
Relapse may occur in about 75% of patients who experienced the resection of hepatic metas-tases from coloreetal cancer. Perioperative chemotherapy with 5-fluorouraeil, leucovorin and oxaliplatin (FOLFOX) can reduce the risk of disease progression in eligible and reseeted patients compared with surgery a-lone. Pre-operative chemotherapy may cause vascular changes and steatohepatitis, which has the potential to in-crease the risks of surgery. A pooled analysis shows a trend of a longer median progression-free survival dura-tion among pest-operative patients who received adjuvant chemotherapy with 5-fluorouraeil and leueovorin-based regimen. Bevaeizumab in either pre-or pest-operative chemotherapy does not increase surgical complications.How to choose the best time and duration of the ebemotherapy needs to be further studied.