Pregnancy outcome in women with lupus nephritis

VernacularTitle:妊娠合并狼疮肾炎的妊娠预后和时机
Author: Jingli ZHENG ; Hui PENG
Publication Type:Journal Article
Keywords: Pregnancy complications; Lupus nephritis; Pregnancy Outcome; Time management
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(4):623-624
CountryChina
Language:Chinese
Abstract: Objective To study the outcome of pregnancy with lupus nephritis. Methods The clinical data of 9 pregnancies with lupus nephritis were retrospectively malyzed. Results Hypertension,proteinuria,injured renal function and abnormal serological marker were complicated with nine patients with lupus nephritis in pregnancy. The outcome of pregnancy was as following:abortion 2 cases,stillbirth 1 case,premature delivery 4 cases,term delivery 2 cases. All neonate survived without malformation. There was no postpartum hemorrhage or death. Patients with active SLE had very high fetal mortality( 100% ). And SLE got worsen in 50% of them. However,fetal mortality rate in pa-tients with controlled or quiescent SLE was 11.1% ,which was much lower than it in other patients(P<0.05). Con-clusion Lupus nephritis should be controlled before pregnancy. Pregnancy outcome could be improved by careful multidisciplinary monitoring and proper usage of adrenal cortical hormone.