The expression level of protein phosphotase-2A in plasma of mild cognitive impairment

VernacularTitle:蛋白磷酸酯酶-2A在轻度认知障碍患者血浆中表达的变化
Author: Shijiang ZHONG ; Zhongsen QU ; Min XUE
Publication Type:Journal Article
Keywords: Mild cognitive impairment; Plasma; Protein phosphotase-2A
From: Chinese Journal of Behavioral Medicine and Brain Science 2009;18(5):404-405
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of protein phosphotase-2A(PP-2A) in plasma in the patients with mild cognitive impairment. Methods The expression of PP-2A was measured by Western-blot in control group(n=11),1-year MCI group(n=10),2-year MCI group(n=10) and 3-year MCI group(n=10). Results The expression of PP-2A in 1-year MCI group(0.96±0.06) and in 2-year MCI group(0.93±0.07) was not obviously lower as compared with control group(1.00±0.08)(P>0.05),but a significant difference was induced between 3-year MCI group and control group(P<0.05),and between 3-year MCI group and 1-year MCI group(P<0.05),but wasn't between 3-year MCI group and 2-year MCI group(P>0.05). Conclusion Lower expression of PP-2A in plasma implies a possible value of MCI diagnosis.