The value of tumor markers in monitoring of non-small cell lung cancer

VernacularTitle:肿瘤标志物在非小细胞肺癌诊断中的价值
Author: Lin CUI
Publication Type:Journal Article
Keywords: Cancinoma,non-small cell lung; Tumor markers,biological
From: Chinese Journal of General Practitioners 2009;08(6):405-406
CountryChina
Language:Chinese
Abstract: One hundred and four patients with non-small cell lung cancer (NSCLC) and 17 patients with benign lung lesions were enrolled in the study. Carcinoembryonic antigen ( CEA), neural specific enolaee (NSE) and cytokemtin 19 fragment (CYFRA21-1) in serum were detected by dectruchemiluminescence method before and after operation. The serum levels of three markers in preoperative NSCLC patients were significandy higher than those of benign pulmonary diseases group (t = 7. 930, 5.568, 6. 110, P <0. 05) ; but there were no significant differences between postoperative NSCLC patients and benign disease patients (t = - 0.034, 1. 242, 0.691, P > 0.05 ). There were significant differences in serum levels of CEA, NSE and CYFRA21-1 before and after operation in NSCLC group ( t = 5.419, 4.722, 5.779, P < 0.05 ) ; but not in benign pulmonary disease group ( t = - 1.244, 0.732, 1. 000, P >0.05). This study indicates that detection of serum CEA, NSE and CYFRA21-1 is of monitoring value for treatment of non-small cell lung cancer.