A study of correlation between insulin resistance and the clinical pathology characters in chronic hepatitis B patients
- VernacularTitle:慢性乙型肝炎患者胰岛素抵抗与临床病理特点相关性研究
- Author:
Bingyu LI
;
Fusheng WANG
;
Huixia LIU
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Insulin resistance
- From:
Journal of Chinese Physician
2009;11(5):603-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between insulin resistance index (HOMA-IR) and the clinical pathology fea-tures in chronic hepatitis B(CHB) patients. Methods ALT and hepatitis B virus loading level and HOMA-IR were measured in 80 CHB pa-tients. Correlation analysis was performed with pathological features of liver tissue. Result Insulin resistance(IR) was much more obvious in patients with severer degree of liver inflammation and fibrosis . HOMA-IR and the insulin level of CHB patients in G3 grade(15.24±7.41,3.51 ± 1.91) and S3 stage (16.65±6. 46,3.79 ± 1.50) were higher than those in G2 grade (10.33 ± 6.28,2.25 ± 1.39) and S2 stage(9.06 ± 4.61,2.02 ± 1.11). The HOMA-IR was positive correlated with the level of age and ALT. Conclusion The development of IR in CHB patients was correlated with age and the degree of liver inflammation and fibrosis.
