The changes and clinical significance of heart fatty acid-binding protein concentrations in children patients after open heart surgery
10.3760/cma.j.issn.1673-4904.2009.17.007
- VernacularTitle:儿童心脏直视术后心肌脂肪酸结合蛋白水平的变化及意义
- Author:
Yonglian WANG
;
Zhongmin WANG
;
Zhijun CHEN
;
Wenjian YAO
;
Jianguo LU
;
Hanchen LI
- Publication Type:Journal Article
- Keywords:
Extracorpereal circulation;
Fatty acid-binding proteins;
Open heart surgery
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(17):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes and clinical significance of plasma heart fatty acid-binding protein(H-FABP)in children after open heart surgery. Methods Forty patients with congenital heart disease(CHD) who had undergone cardiac operation with cardiopulmonary bypass(CPB) were selected in this study,and were randomly divided into two groups (each 20 cases): cold crystalloid cardioplegia perfusion group (Ⅰ group) and cold blood cardioplegia perfusion group(Ⅱ group). Blood samples were taken to check the plasma H-FABP concentration before CPB and different time after CPB. Plasma H-FABP concentration was estimated by enzyme-linked immunosorbent assay (ELISA). Results The difference of plasma concentration of H-FABP before operation was not obvious between Ⅰ group and Ⅱ group. The plas-ma concentration of H-FABP intraoperation and different time after operation was higher than that before anesthesia induction obviously in two groups, and Ⅰ group rose more significantly [(50.13±3.98) μg/L vs (39.27±4.22) μg/L, P<0.01]. Conclusions H-FABP concentration after operation is higher than that before operation significantly. H-FABP can be used to judge myocardial damage earlier as a sensitive index, because plasma concentration of H-FABP increases significantly after open heart surgery, and its peak emerges early. Compared with cold crystalloid cardioplegia,the myocardial protection of cold blood cardioplegia is better.
