24 h esophageal pH monitoring in patients with gastroesophageal reflux-induced cough treated with omeprazole
10.3760/cma.j.issn.1671-7368.2009.06.012
- VernacularTitle:胃食管反流性咳嗽患者24h食管pH值监测的临床意义
- Author:
Liping ZOU
;
Jieping YU
;
Hesheng LUO
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux;
Cough;
pH;
Omeprazole
- From:
Chinese Journal of General Practitioners
2009;08(6):389-391
- CountryChina
- Language:Chinese
-
Abstract:
To monitor the 24 h esophageal pH in patients with gastroesophageal reflux-induced cough (GERC) before and after omeprazole treatment. Methods The prospective study was conducted in Department of Gastroenterology, People's Hospital of Wuhan University from February 2007 to April 2008. Twenty patients with GERC received 40 mg of omeprazole daily and underwent 24 h esophageal pH monitoring before and 8 weeks after omeprazole treatment. Six parameters by Johson and Demeester were adopted for evaluation: pereentage of total time with pH <4, percentage of uptight reflux time with pH <4, percentage of supine reflux time with pH < 4, the number of reflux episodes with pH < 4, the number of reflux episodes longer than 5 min and the percentage of longest reflux duration. Results The values of six parameters before treatment were 13.5±8.5, 12.2±4.0, 15.8 ±4.1, 56 ± 13, 4. 15 ± 1.87 and 26.2 ± 16. 5 respectively; while those after treatment were 2.7± 1.3, 3.9 ± 1.9, 1.9 ± 1.0, 18 ± 11, 1.24 ±0.65 and 7.4 ± 2. 1. There were significant differences in these six parameters between pre-treatment and post-treatment (P<0.01 ). Conclusion The 24 h esophageal pH monitoring shows that omeprazole is effective in treatment of GERC by decreasing esophageal pH.
