Analysis of survival in 106 patients with amyotrophic lateral sclerosis
10.3760/cma.j.issn.1006-7876.2009.06.011
- VernacularTitle:肌萎缩侧索硬化患者106例生存分析
- Author:
Xiaoxuan LIU
;
Dongsheng FAN
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Survival analysis;
Prognosis
- From:
Chinese Journal of Neurology
2009;42(6):402-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the factors related to amyotrophic lateral sclerosis (ALS) prognosis in a retrospective study.Methods One hundred and six patients were evaluated with ALS enrolled in our hospital from January 1994 to December 2004.The patients were monitored with a standard evaluation form,which recorded clinical features,function rating scale (FRS) and forced vital capacity (FVC) every 3 or 6 months from visit to death or having tracheostomy.Results Mean age at onset was (52.1±10.5) years.According to revised El Escorial diagnostic criteria (EEDC),52 patients had definite ALS,37 probable ALS,17 possible ALS.The median survival time from symptom onset was 35 months (95% CI 30-40 months).In the univariate analysis,survival was significantly related to lesion site,lag time from onset to diagnosis and predicted FVC at diagnosis (Log rank 6.84,43.30,4.78,all P < 0.05).In the Cox multivariate model,lag time from onset to diagnosis was significantly related to survival (Wald 20.221,hazard ratio 0.351,P<0.05).Age,sex,EEDC classification,FRS at diagnosis were not related to survival.Conclusion Lag time from onset to diagnosis is a strong predictor of survival,which suggests that progression rate is highly related to survival and further study is needed.
