Clinical effects of single Sialic four hexose sodium injection ganglioside in treating the periventricular leukomniacia

VernacularTitle:单唾液酸四己糖神经节苷脂钠注射液治疗早产儿脑室周围白质软化疗效观察
Author: Shuyan WANG
Publication Type:Journal Article
Keywords: Premature infants; Periventricular leukomalacia; Skull B-ultrasonography; Gangliosides sodium
From:Clinical Medicine of China 2009;25(6):596-597
CountryChina
Language:Chinese
Abstract: Objective To study the clincial effects of of single Sialic four hexose sodium injection ganglio-side (GM1) in treating periventricular leukomalacia of premature infants. Methods 41 cases of periventricular ]eukomalacia patients were divided into GMI treatment group (n=22) and control group (n=19). The treatment group were given another GM1 treatment. Dynamic observation of changes in B-head information was conducted. Re-stilts 6 months after birth, 8 cases(36.4%) in treatment group and 13cases (68.4%)in control group occurred with ventricular dilatation (χ28.85, P<0.05). Nervous system examination revealed there were 5 cases (22.7%) in treatment group and 10 cases (52.6%) in control group with limited performance of the Board of mus-cle tone and abnormal movements (χ2 3.93, P<0.05); 4 cases in treatment group (18.2%) and 9 cases (47.4%) of control group had mild cognitive impairment and mental retardation according to nervous system sequel-ae(χ24.01,P<0.05). Conclusion GM1 can effectively treat periventricular leukomalacia and reduce abnormal movements.