The brain protection of Naloxoneon patients with acute organ phosphorus pesticide poisoning
10.3760/cma.j.issn.1008-6315.2009.06.034
- VernacularTitle:纳洛酮对重度急性有机磷农药中毒脑损害的干预作用
- Author:
Yonghong XIE
;
Yupeng LIU
;
Chongyang ZHANG
- Publication Type:Journal Article
- Keywords:
Naloxone;
Organ phosphorus poisoning;
Brain injuries;
Brain protection
- From:Clinical Medicine of China
2009;25(6):657-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect and significance of Naloxane on the brain function in patients with acute organ phosphorus pesticide poisoning. Methods 106 patients with acute organ phosphorus pesti-cide poisoning were randomly allocated to two groups according to the hospitalized date, the NX group(n=54) and the normal group(n=52). The two groups received the same basic treatment and the dynamic monitor about the changes of the β-EP and MDA levels in each groups, and the NX group was given additional treatment with 0.8 mg Naloxone-intravenous injection every 20 minutes till consciousness recovering or symptoms improved. Results The time of recovering consciousness was (16.71±3.17)h in NX group and (20.84±3.25)h in control group. β-EP and MDA were higher than normal before treatment in all patients (P<0.01), and were significantly reduced after treatment in NX group (P<0.05), the control group had mild change after treatment. Conclusion Relating to the inhibition of oxygen free radicals, Naloxone can reduce time of recovering consciousness and can protect the injured brain of the patients with acute organ phosphorus pesticide poisoning.
