Low-density lipoprotein immune complexes in patients with type 2 diabetes

VernacularTitle:2型糖尿病患者血清低密度脂蛋白免疫复合物的检测及临床意义
Author: Xueqin WANG ; Shiwei CUI ; Yan JIN ; Guohua TAO ; Jinfeng CHEN ; Gang WU
Publication Type:Journal Article
Keywords: Diabetes mcllitns,2 type; Lipoproteins,LDL
From: Chinese Journal of General Practitioners 2009;08(6):407-409
CountryChina
Language:Chinese
Abstract: This study was designed to observe the clinical value of low-density lipoprotein immune complexes (LDL-ICs) in patients with type 2 diabetes mellitus (T2DM). Fifty-four patients with type 2 diabetes + macroangiopathy (DM-MA group), 48 patients with type 2 diabetes (DM group), 45 patients with macroangiopathy ( MA group), and 30 normal controls ( NC group) were enrolled. LDL-ICs levels in the DM-MA group were significantly higher than those in the other three groups. The levels of LDL-ICs in the MA group were higher than those in the NC and DM groups. There was a significant difference in LDL-ICs between the DM and NC groups. LDL-ICs levels were positively related with body mass index (BMI), glycesylated hemoglobin Alc(HbAlc), blood pressure, total cholesterol, and triglyceride. There was no significant relationship between low-density lipsprotcin cholesterol and LDL-ICs. A significantly negative correlation was recorded between high-density lipoprotein cholesterol and LDL-ICs. Our study suggests that LDL-ICs, blood pressure, and HbAlc may be risk factors of macroangiopathy in type 2 diabetic patients.