Effects of metformin on plasma lactic acid level in patients with type 2 diabetes

VernacularTitle:二甲双胍对2型糖尿病患者血乳酸水平的影响
Author: Ling JIAO ; Ying Lü ; Yingluo ZHANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Metformin
From: Chinese Journal of General Practitioners 2009;08(6):422-423
CountryChina
Language:Chinese
Abstract: One hundred and thirty-six adult patients with type 2 diabetes ( ≥40 years, body mass index > 24) were assigned to the low-dose Mefformin, high-dose Mefformin, and control groups. Plasma lactic acid level was detected with ultraviolet enzyme kinetics assay. Our data showed that plasma lactic acid of the low-dose or high-dose mefformin group was significantly higher than the control group (2.314 vs. 2.511, P<0.05 ), although there was no significant difference between the low-dose and the high-dose Mefformin group. In all the 3 groups, increased lactic acid ( > 2. 2 mmol/L) was found in some patients ( Mefformin group vs. Control group: X2 = 7.43, P < 0.05 ), and no lactic acid > 5.0 mmol/L was found. Insulin resistance index and hemoglobin Alc were similar between the 3 groups. Thus, mefformin may not increase the risk of lactic acidosis in diabetic patients with normal cardiorespiratory and renal function.