Expression of epidermal growth factor receptor of cervical carcinoma and its correlation with prognosis
10.3760/cma.j.issn.1008-6315.2009.06.010
- VernacularTitle:宫颈癌中表皮生长因子受体的表达与临床预后的相关性研究
- Author:
Linghong DENG
;
Shuyu FENG
;
Jiali KANG
;
Yanna ZHANG
;
Qiaoer LIN
;
Miaoling NIE
;
Haiyan CHENG
;
Jinrui SUN
- Publication Type:Journal Article
- Keywords:
Cervical carcinoma;
Cervical intracpithelial neoplasia;
Epidermal growth factor receptor;
Immunohistochemistry
- From:Clinical Medicine of China
2009;25(6):590-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of epidermal growth factor receptor (EGFR) in cervical car-cinoma and cervical intraepithelial neoplasia(CIN),and to elucidate its relation with the genesis, infiltration, metas-tasis and prognosis of cervical carcinoma. Methods EGFR was determined by means of S-P immunohistochemistry in tissue of 100 cases of cervical carcinoma,60 cases of CIN and 40 cases of controls. Results The overexpression rates of EGFR were 0% (0/40), 51.67% (31/60),78.00% (78/100), respectively in normal cervical epithelium, CIN and cervical tumor tissues. The overexpression rate of EGFR was significantly higher in cervical tumor tissue than in control group(P<0.01). The overexpression of EGFR didn't demonstrate significant association with clinical staging, tumor size, pathological type, differentiation, cervical invasion depth, cervical canal invasion, lymphnode me-tastasis or the prognosis of cervical neoplasm (P>0.05). Conclusion Overexpression of EGFR is worsened with the severity of cervical lesion, suggesting that overexpression of EGFR is correlated with the genesis of cervical neo-plasms,which may be a valuable biological indicator of cervical carcinoma,but is not correlated with clinical patho-logical features and prognosis of cervical carcinoma.
