25 % insulin lispro( Mix 75/25 ) intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabetie patients

VernacularTitle:精蛋白锌重组赖脯胰岛素混和注射液对初诊糖尿病血糖及胰岛功能的影响
Author: Xiaoyan LIN ; Yishan FANG ; Xiaopeng ZHENG
Publication Type:Journal Article
Keywords: Type 2 diabetes mellitus; Plasma glucose; Iusulin
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(5):847-848
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of 25% insulin lispro( Mix 75/25) intensive treatment on plasma glucose and pancreatic function in newly diagnosed type 2 diabets. Methods Sixty patients with newly diagnosed type 2 diabetes were treated by 2 months 25% insulin lispro(Mix 75/25) treatment. The level of fasting plasma glucose (FPG) ,2 hours postprandial glucose (2hPG), glycosylated hemoglobin A1c (HbA1c), the fasting insulin and Cpeptide, insulin resistance index (HOMA-A), insulin secretion index (HOMA-B), insulin sensitivity index (ISI) and the ratio of fasting insulin to fasting glucose(FINS/FPG) were compared before and after 25% insulin lispro(Mix 75/25) treatment. Results After the treatment,FPG,2hPG,HbA1c and HOMA-A were significantly decreased( all P＜0. 01 ) ;the fasting insulin and C-peptide,FINS/FPG, HOMA-B and ISI greatly increased( all P＜0. 01 ). Conclusion 25% insulin lispro( Mix 75/25) intensive treatment can effectively improve plasma glucose and pancreatic function in newly diagnosed type 2 diabetes.