Evaluation the liver reservation functions of patients with severe hepatopath of nonage treated with plasma exchange by 13C-methacetin breath test
10.3760/cma.j.issn.1008-6315.2009.06.014
- VernacularTitle:13C-美沙西汀呼气试验评估早期重症肝病患者血浆置换前后肝储备功能的变化
- Author:
Xia ZHAO
;
Aimin DENG
;
Xuesong FU
;
Shuxin YIN
;
Yanhua ZHANG
;
Yugang WANG
;
Xiaojuan DENG
;
Xiaofang ZHANG
- Publication Type:Journal Article
- Keywords:
13C-methacetin breath test;
Severe hepatopath of nonage;
Plasma exchange
- From:
Clinical Medicine of China
2009;25(6):598-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To judge the effect of plasma exchange (PE) to the patients with severe hepatopath of nonage according to evaluating the change of the liver function of reserve with 13C-methacetin breath test. Methods There are two groups: the case group and the control group. Each group has 30 patients. The patients in the case group were treated by PE. All the patients received 13C-methacetin breath test at before or one week after treatment. MVmax40, CUM40 and CUM120 were present. At the same time, clinical symptoms, glutamate-pyruvate transaminase (ALT), total bilirubin (TBiL) and prethrombin active (PTA) were observed. Results MVmax40, CUM40, CUM120 and PTA were higher, ALT and TBiL were lower in the case group after treatment (t=4.679, 4.752, 5.048, 5.413, 6.208, 7.413, P=0.000,P<0.01). After a week, MVmax40, CUM40, CUM120 and PTA were higher, ALT and TBiL were lower in the case group than that in the control group (t=2.260, 2.247, 2.476, 4.017, 3.250, 3.658, P<0.05). The total effective rates in the case group and the control group were 83.3 % (25/30) and 43.3 % (13/30),which are significant different(χ2 10.335,P<0.01). Conclusion PE can im-prove the liver reservation functionin the severe hepatopath of nonage.
