Plasma level of retinol binding protein 4 and its correlation in patients with essential hypertension of Kazakans
10.3760/cma.j.issn.1008-6315.2009.06.023
- VernacularTitle:哈萨克族原发性高血压患者血浆视黄醇结合蛋白4水平及其相关性研究
- Author:
Dongxia JIA
;
Zhong WANG
;
Li WANG
;
Jun YANG
;
Yun YANG
;
Juncang DUAN
;
Wangqiang ZHANG
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Retinol binding protein 4;
Insulin resistance;
Kazakans
- From:Clinical Medicine of China
2009;25(6):629-631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the plasma level of retinol binding protein 4 (RBP4) in patients with es-sential hypertension (EH) of Xinjiang Kazakans and the relations between plasma RBP4 level and blood pressure, blood lipids,blood glucose, insulin, and HOMA-IR. Methods 81 Kazakans cases who were investigated between August and November of 2008 were selected as subjects. They were divided into EH group(n=41)and control group (n=40). Blood pressure was measured. Fasting venous blood was drawn to detect the plasma RBP4, fasting insulin (FINS), fasting plasma glucose(FPG), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol (HDL-C)、low density lipoprotein cholesterol (LDL-C), apoprotein-A1 (APO-A1) and apoprotein-B (APO-B), and concentration in EH group was significantly higher than that in control group[ (32.74±9.93) mg/L vs (21.92± pressure (DBP),FPG,and HOMA-IR in EH group(r,=0.618,0.775,0.565,0.317,0.369,P<0.01 or P< showed that SBP was independent factor to affect the RBP4 level in EH group(Standardized Coefficients is 0.591, t=5. 695, P=0.000). Conclusion The plasma RBP4 concentration is increased in patients with EH of Kazakans, and is positively correlated with SBP,DBP,FPG,HOMA-IR in EH group. RBP4 may involve in the development of EH by promoting insulin resistance.
