Mechanism and Interference therapy of HMGB1 after Ischemia/Reperfusion Injury
10.3760/cma.j.issn.1673-4203.2009.06.025
- VernacularTitle:术后缺血再灌注时HMGB1的损伤机制及干预治疗进展
- Author:
Qiang ZHAO
;
Zhenxiao JIN
;
Dinghua YI
;
Guanli FENG
- Publication Type:Journal Article
- Keywords:
high mobility group box 1 (HMGB1);
ischemia/reperfnsion injury;
inflammation factors;
organ transplantation;
cardiopulmonary bypass
- From:
International Journal of Surgery
2009;36(6):424-427
- CountryChina
- Language:Chinese
-
Abstract:
After operations such as organ transplantation or cardiopulmonary bypass complicated with is-chemia/reperfusion injury,activated inflammatory cells can express and secret HMGB1,and cooperate with other inflammation factor to induce tissue damage.The mechanism is HMGB1 actives such receptors as TLRs,RAGE,TM,and NF-κB transcription factor,P38MAPK pathway,induce releasing of HMGB1 itself and other inflammation factors.Different with sepsis,HMGB1 emerges much earlier,lasting longer.Inter-ference therapy of HMGB1 could effectively decrease secretion of HMGB1 after ischemia/reperfusion injury.
