The heterogeneous of large lymphocytic leukemia:6 cases report and clinical analysis
10.3760/cma.j.issn.1008-6706.2009.05.017
- VernacularTitle:表现异质的大颗粒淋巴细胞白血病6例临床分析
- Author:
Hongyu ZHANG
;
Yihui MAO
;
Qingxiang MENG
;
Jin LIU
;
Liping PANG
;
Jun WANG
;
Lei XU
;
Jia FENG
;
Wenli ZHANG
;
Qian ZHANG
;
Lihua SUN
;
Fengluan ZHONG
;
Haichan XU
;
Jiren YU
- Publication Type:Journal Article
- Keywords:
Genetic Heterogeueity;
leukemia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(5):800-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and study the diagnosis of large granular lymphocyte leukemia(LGLL).Methods To report and discuss six cases weth LGLL we have found. Results 2 of T-LGLL and lof NK-LGLL had indolent process, mainly presenting with anemia and splenomegaly and good response to treatment, while; 1 of T-LGLL and 2 of NK-LGLL had aggressive process, their clinical characters are obviously general symptom, hepatomegaly,splenomegaly,these disease develop quickly and have bad prognosis. The immunophenotype of indolent LGLL is distinct from aggressive cases. Conclusion As a group of heterogeneous disease,its diagnosis should be based on clinical manifestation and immunophenotype and differentiated it carefully.
