Effect of batroxobin on endothelin and calcitonin gene-related peptide in patients with acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2009.05.002
- VernacularTitle:巴曲酶对脑梗死患者血浆内皮素及降钙素基因相关肽水平的影响
- Author:
Min ZHOU
;
Jin FENG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Endothelins;
Calcitonin gene-related-peptide;
Batroxobin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(5):771-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of batroxobin on the plasma levels of endothelin (ET) and calcitonin gene-related peptide(CGRP) in patients with acute cerebral infarction(ACI). Methods 60 patients with ACI were randomly divided into therapy group(n = 30) and control group(n = 30),500 ml of 5% GS plus 1.0g ramme of Troxerutin was intravenously dripped par day and ticlopidine 250mg/day in the control group. Based on the control group therapy,Batroxobin was intravenously dripped with 10U on the 1st day and 5U on the 3rd and 5th day for seven days. The plasma levels of ET and CGRP were detected pre and post treatment by radioimmunoassay. Results Plasma levels of ET and CGRP in batroxobin therapy group post treatment ( 81.25±27.38 ) ; ( 44. 13±13.30) ng/L were significantly different from those pre treatment(109. 83±38.24) ; (24. 73±13.59) ng/L (all P＜0. 01 ) ,and were also significantly different from those post treatment in the control group(98.07±30. 39) ; (37.02±12. 41 )ng/L (all P＜0. 01 ). Conclusion Batroxobin can accommodate the equilibration between ET and CGRP, and protect brain cell and blood vessel endothelial cell.
