Effect of Fox01 expression on islet β-celis apoptosis in diabetic rat
10.3760/cma.j.issn.1000-6699.2009.03.025
- VernacularTitle:糖尿病大鼠胰岛β细胞Fox01表达对细胞凋亡的影响
- Author:
Danyan CHEN
;
Huacong DENG
;
Jing NAN
;
Zhengping FENG
;
Qiang LIU
;
Dengyou QIN
;
Hengyu ZHOU
- Publication Type:Journal Article
- Keywords:
Fox01;
Pancreatic islet β-cell;
Caspase-3;
Apoptosis;
Diabetes mellitus,experimental
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):320-323
- CountryChina
- Language:Chinese
-
Abstract:
SD rats were injected with streptozotocin and fed with high fat diet,used as type 2 diabetic model. Transcription factor Fox01 [in nucleus (15.00±1. 15 vs 6.45±0. 62) %, P<0.05], Caspase-3 [(23.73 ±1.48 vs 6.30±2.20)% ,P<0.01] expressions in pancreatic istet β cells and the positive rate of islet β cells apoptosis[(22.29±1.84 vs 6.25±2.42) %, P<0.01] in diabetic rats were higher than those of control rats. The islet cells which highly expresed Fox01 (in nucleus)and caspase-3 were just the apoptotic islet cells. Therefore,Fox01 may be involved in regulating apoptosis of islet β cells in type 2 diabetes.
