Treatment of deep wound infection with fibrin glue amikacin complex
10.3760/cma.j.issn.1001-8050.2009.05.177
- VernacularTitle:纤维蛋白胶丁胺卡那霉素复合体防治深部创口感染
- Author:
Zhijian MA
;
Hongchang YANG
;
Zhong CHEN
;
Zhaoxiang WU
;
Tao LI
;
Gang CHENG
;
Peng LIAO
;
Yi OU
;
Canzhang LI
;
Tao HAN
- Publication Type:Journal Article
- Keywords:
Fibrin tissue adhesive;
Amikacin;
Wound Infection;
Leukocyte;
Neutrophil
- From:
Chinese Journal of Trauma
2009;25(6):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the efficiency of fibrin glue amikacin complex in controlling infection by observing the changes of leukocyte and neutrophilic granulocyte classifying counts after fibrin glue amikacin complex treated deep wound. Methods Clinical case-control study was used in the study. All patients were divided randomly into test group (100 patients) and control group (100 pa-tients), matched by wound location, wound size, time from injury to operation, combined injury and gen-eral antibiotics use to compare leukocyte and neutrophilic granulocyte classifying counts between both groups and observe possible toxic and side-effect in test group. Results Firstly, the test group and control group had the comparability in aspects of gender distribution, average age and injury mechanism (P >0.05). Secondly, there was statistical difference in classifying counts of leukocyte and neutrophilic granulocyte in the test group at different time points (P <0.05). The classifying counts of leukocyte and neutrophilic granalocyte peaked at 24 hours after operation, then decreased with treatment time and reached the lowest at 24 days after surgery or at day 1 before discharge. Thirdly, there existed statistical significance upon leukocyte counts in the test group and control group except for at day 1 after operation (P > 0.05), with lower counts in test group than control group. In aspect of neutrophil classifying counts, there was statistical significance (P < 0.05) at other time points in beth groups except for time points at days 1,2 and 12 (P >0.05). The test group had lower neutrophil classifying counts compared with con-trol group at different time points. Conclusion The fibrin glue amikacin complex has good clinical effort and high security, with no toxic or side effort in treatment of deep wound infection, and is worth clinical applicaiton.
