Analysis of risk factors for venous thrombosis associated with the placement of peripherally inserted central catheters in patients with malignant tumors during the course of chemotherapy
10.3760/cma.j.issn.1672-7088.2009.06.044
- VernacularTitle:肿瘤化疗患者PICC置管后静脉血栓形成的危险因素分析及护理干预
- Author:
Suzhen WEI
;
Aihong WANG
;
Guixin LI
;
Zhong LU
;
Xuewei ZHOU
- Publication Type:Journal Article
- Keywords:
Malignant tumor;
Peripherally inserted central catheters;
Venous thrombosis;
Risk factors
- From:
Chinese Journal of Practical Nursing
2009;25(17):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the induced-factors levels of venous thrombosis associated with the placement of peripherally inserted central catheters (PICC) in patients with malignant tumor,and establish intervention model accordingly. Methods 40 patients complicated with venous thrombosis after PICC were set as the thrombosis group, 40 patients without venous thrombosis were selected as the no-thrombosis group, 30 healthy cases were selected as the control group. All cases' serum samples were ob-tained to measure the levels of molecular biomarkers of the coagulation system, platelet parameters and molecular biomarkers of the fibrinolysis system. The results of the three groups were assessed. Results Patients in the thrombosis group were reported significantly higher levels of vWF, GMP140,TAT than those in both two other groups, but lower levels of ATⅢ. Higher levels of MPV and PCT were found in the throm-bosis group than those in both two other groups.Tthe data also showed higher PLG and PAI levels and lower levels of PLM in the thrombosis group. Conclusions From this study it shows that patients with malig-nant tumors during the placement of PICC have evident hypercoagnlahility, high- activated platelet and se-vere pre- thrombosis state caused by PICC. In treatment of malignant tumor patients with PICC, the level of coag-ulation system molecular markers, platelet parameters,fibrinolysis molecular markers shoud be used as a clinical routine and as the index of early intervention and evaluation of the PICC.
