The changes and significances of eotaxin levels in induced sputum from asthmatic patients
10.3760/cma.j.issn.1008-6706.2009.06.022
- VernacularTitle:哮喘患者诱导痰嗜酸细胞趋化因子的改变及其意义
- Author:
Liqin WANG
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Induced sputum;
Airway inflammation;
Eotaxin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(6):1000-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of eotaxin (ehemotacfie factor of eosinophils) in pathogenesis of eosinophilie airway inflammation and airflow obstruction. Methods 45 eases of patients in exacerbations with bronchial asthma (A group) and 25 eases of healthy volunteers as controls (B group) have participated in lung func-tion test and sputum induefion. The concentration of eotaxin was measured with sandwich enzyme-linked immunosor-bent assay (ELISA). Results The differences of the eosinophil (EOS)/leukoeyte (Leu)% in the two groups are significant (P <0.05) ; the differences of the eotaxin in the two groups is also significant (P < 0.05) ; the EOS/Leu% and the level of eotaxin are significantly inversely correlated with the percentage of the first second forced ex-piratory volume/predicted value (FEV1%) (P < 0.001). The level of eotaxin in induced sputum is significantly positively correlated with the EOS/Leu% in A group (P<0.001). Conclusion Eotaxin poasiblely partieulatesin e-osinophilic airway inflammation and airflow obstruction in asthmatic patients by selective chemotactic activity on eosin-ophil, and eosinophil release a series of inflammation medium that induce the exacerbation of asthma.
