Matrix metalloproteinases and the restenosis after injury of arterial intima
10.3760/cma.j.issn.1673-4203.2009.06.024
- VernacularTitle:基质金属蛋白酶与动脉内膜损伤后再狭窄的研究
- Author:
Shenggang WANG
;
Xiaohu GE
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinases;
extracellular matrix;
vascular remodeling;
restenosis
- From:
International Journal of Surgery
2009;36(6):421-423
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade various components of the extracellular matrix (ECM).Both animal expodments and clinical sample analysis have shown that balance in expression and activation of MMP and inhibition by tissue inhibitors of matrix metallo-proteinase (TIMP)is critical for the development of stenotic change.This review article focuses on the role of MMP relevant to restenosis after vascular injury.
