The expression and significance of intergrin alphavbeta3(αvβ3)in the kidney of patients with IgA nephropathy
- VernacularTitle:整合素αvβ3在IgA肾病肾组织中的表达和意义
- Author:
Ruihua REN
;
Shuxia FU
;
Lin TANG
;
Jianrong WANG
- Publication Type:Journal Article
- Keywords:
Intergrin alpha Vbeta3;
Glomerulonephritis,IGA
- From:
Journal of Chinese Physician
2009;11(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance intergrin alphavbeta3(art33)in the kidney of patients with IgA nephropathy(IgAN).Methods lmmunohistochemistry wag applied to detect the expression of avl33。fibronectin(Fn)and Connective tissue growth factor(CTGF)in the kidney of patients with IgAN.and correlation analysis was done with pathology and clinic index.Result With the development of the disease,the expression of etvl33 was gradually increased in the glomemlar capillary endothelial cell.and mesansial cell as well as glomerular crescent.The positive area ratio of αvβ33 in renal glomerulus was(16.18±o.98,19.58±0.99,28.35±1.99,17.72±2.17)％respectively in grade I～Ⅳ pathological changes.Among all the groups,the expression of αvβ33 was the strongest in grade Ⅲ,while decreased in grade Ⅳ(P
