A systematic review of the effect of radioiodine.131 in treatment of pulmonary metastases from differentiated thyroid carcinoma and the main prognostic factors
10.3760/cma.j.issn.1000-6699.2009.03.003
- VernacularTitle:放射性131Ⅰ治疗分化型甲状腺癌肺转移的疗效及其主要预后因素的系统评价
- Author:
Da MU
;
Xiaojuan MA
;
Shuping LI
;
Anren KUANG
- Publication Type:Journal Article
- Keywords:
Differentiated thyroid carcinoma;
Pulmonary metastases;
Radioiodine treatment;
Prognostic factor
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):250-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of radioiodine-131 (131Ⅰ) on treatment of pulmonary metastases from differentiated thyroid carcinoma and the main prognostic factors. Methods Five databases were retrieved and all published studies which analyzed the effect of 131Ⅰ on pulmonary metastases from differentiated thyroid carcinoma and the main prognostic factors were systematically reviewed. The data about the impact of 131Ⅰ treatment and the main prognostic factors on the 5-yr and 10-yr survival rates of the patients were abstracted. RevMan 4.2 software was used to statistically analyze. Results Eleven retrospective cohort studies were included. The pooled results suggested that the 5-yr survival rates of the patients who received 131Ⅰ therapy and who did not received 131Ⅰl therapy were 74.9% and 27.1% , respectively ;The lO-yr survival rates(P<0.01)of the two groups were 60.8% % 12.2% , respectively;The difference between them had statistical significance (P<0.01). The 5-yr and 10-yr survival rates of the patients only with pulmonary metastases were higher than those of the patients with multiple metastases (P<0.01). The 5-yr (P = 0.01) and 10-yr (P = 0. 002)surviv10al rates of the patients only with papillary thyroid carcinoma were higher than those of the patients with follicular thyroid carcinoma. The 5-yr and 10-yr survival rates of male and female patients were similar(P>0.05). Conclusions 131Ⅰ treatment increases the 5-yr and 10-yr survival rates of patients with pulmonary metastases from differentiated thyroid carcinoma. The extent of metastases and the histologie type of differentiated thyroid carcinoma are two main predicting factors of prognosis. The 5-yr and 10-yr survival rates of patients are not influenced by gender.
