Effect of probiotcs on ulcerative colitis in mice
- VernacularTitle:益生菌对小鼠溃疡性结肠炎的影响
- Author:
Dan LIU
;
Fanggen LU
- Publication Type:Journal Article
- Keywords:
Probiofics/PD;
Colitis,ulcerative/DT
- From:
Journal of Chinese Physician
2009;11(6):740-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of COX-2 in the DSS-induced UC mouse model and the effects of probiotics in the pathogenesis of UC. Methods DSS-induced UC mouse model was used in the study. A total of 60 mice were divided into 6 groups (Blank control group, DSS model group, Saline group, SASP group, Lactovacillus group and Bifidobactefia group). After 8 days, all mice were sacrificed. Histological injury score and pathological change and COX-2 in mucous of colon membrane were evaluated. Results The stages and histological changes were obviously improved and the expression of COX-2 in the colonic mueosa of mouse with UC was decreased when using probiotics and SASP. Conclusions Lactobacillns and Bifidobacterla can decrease the expression of COX-2 in the colonic mucosa of mouse with UC. The effect has no difference between SASP and probiotic group.
