Protective effects of curcumin on lung injury in the liver early ischemia/reperfusion in rats
- VernacularTitle:姜黄素对大鼠早期肝缺血再灌注损伤肺的保护作用
- Author:
Jinjian XIANG
;
Fu TIAN
;
Mingzhong LI
;
Xuefeng JIANG
;
Qin DENG
;
Shiqiang SHEN
;
Shilun TONG
;
Benjin CHEN
- Publication Type:Journal Article
- Keywords:
Curcumin/PD;
Reperfusion injury/PC;
Liver diseases/DT;
Lung/DE
- From:
Journal of Chinese Physician
2009;11(6):763-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore protective effects of curcumin on lung injury in the early hepatic ischemia/reperfsion (reperfusion for 1 and 3 hour) inrats. Methods Wistarratswererandom]y divided into the fo]]owinggroups: GroupA (shamoperation), group B (control group) and group C (cureumin applied). Contents of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO) in lung tissues were determined to evaluate the protective effect of eurcumin on lung injury in the injury of isehemia/ reperfusion. Results Curcumin relieved edema of diaphragmatic wall and exudation of blood cell and white cell in pulmonary alveoli. Curcumin increased the contents of SOD, CAT and decreased contents of MDA, MPO in lung tissue. Conclusion By repressing the generation of oxygen free radical and infiltration of polymorphonuclear leukocyte in lung tissue, curcumin can relieve lung injury in the early hepatic ischemia/repeffusion.
