Expression of C-reactive protein in visceral adipose tissue of rat with high fat diet
10.3760/cma.j.issn.1000-6699.2009.03.026
- VernacularTitle:高脂喂养大鼠内脏脂肪组织C反应蛋白的表达
- Author:
Lingli DAI
;
Xiaoyong LI
;
Ning LIN
;
Yan DONG
;
Qing SU
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Obesity;
Adipose tissue;
High-fat diet
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):323-325
- CountryChina
- Language:Chinese
-
Abstract:
The abdominal visceral fat content in obese SD rats induced by high fat diet for 10 weeks was significantly higher than that in control group [(26±6 vs 13±3)g,P<0.01] ,along with increased CRP mRNA expression in abdominal visceral fat (0.901±0.085 vs O. 402±0.036, P<0.01). As compared with normal control group, in the high fat group the concentrations of CRP in portal vein [(743.8±95.8 vs 558.3 ±118.3) mg/L, P<0.01] and peripheral vein[(596.3±38.9 vs 485.8±30.2) mg/L,P<0. 05] were higher. The concentration of CRP in portal vein was significantly higher than that in peripheral vein in high fat diet group(P<0.01) ,but this was not evident in control group. These results suggest that the increased CRP expression in visceral adipose tissue may partially account for the elevation of serum CRP in obesity.
