Clinical-pathological features and prognosis of thrombotic tbrombocytopenic purpura in patients with lupus nephritis
10.3760/cma.j.issn.1007-7480.2009.06.006
- VernacularTitle:狼疮肾炎伴血栓性血小板减少性紫癜的临床病理特征及预后分析
- Author:
Ping LIU
;
Zheng TANG
;
Haitao ZHANG
;
Caihong ZENG
;
Zhihong LIU
;
Leishi LI
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Purpura,thrombotic thrombocytopenic;
Clinical-pathological features Prognosis
- From:
Chinese Journal of Rheumatology
2009;13(6):381-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical-pathological features, treatment and prognosis of thrombotic thrombocytopenic purpura in patients with lupus nephritis (LN). Methods A retrospective ana-lysis was carried out based on the clinical-pathological data for the treatment and prognosis of eight patients with LN related TIP. All patients had thrombocytopenia and hemolytic anemia, neurological symptoms and renal dysfunction. Six patients had fever. Results All 8 patients had sudden-onset of rapid progressive glomeurlonephritis (RPGN), one patient with continuous gross hematuria, the pathological features of these patients revealed TMA lesions. Immune suppressive therapy was initiated and blood purification therapy were applied in seven patients. Three cases had plasmapheresis and (or) immunoabsorption. One case was lost during follow-up, the other seven patients were followed with period at one year. One patient died, three patients went into peritoneal dialysis in which one of them was changed to hemodialysis finally. The other three patients had stable renal function. Conclusion The LN patients with TTP had severe clinical-patho-logical changes, rapid progressive and poor outcome, so we should diagnose and treat these patients as early as possible.
