Neuroprotective mechanisms of SIRT1
10.3760/cma.j.issn.1673-4165.2009.02.014
- VernacularTitle:SIRT1的神经保护机制
- Author:
Dujuan SHA
;
Yun XU
- Publication Type:Journal Article
- Keywords:
sirtuin;
neuroprotective agents;
apoptosis
- From:
International Journal of Cerebrovascular Diseases
2009;17(2):144-148
- CountryChina
- Language:Chinese
-
Abstract:
Sirtuin is a type of deacetylase acted on histone. Sirtuin 1 (SIRT1) is the most homologous to the homologue of silent information regulator 2 (SIR2) in mammals. Its main function is to regulate the body energy metabolism, cell senescence and response to stress. SIRTI inhibits apoptosis through the interaction of several transcription factors involving in stress response. It is a neuroprotective gent.
