optimization of tobramycine 0.3% ophthalmic formulation
- Author:
Hoang Ngoc Hung
- Publication Type:Journal Article
- Keywords:
Tobramycine 0.3%
- MeSH:
Ophthalmic Solutions;
Tobramycin
- From:Pharmaceutical Journal
2005;354(10):13-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The factors selected as an independent variable to study included antioxidant dinatri EDTA and viscosity enhancers PVP. Value of pH and percent of remained tobramycine contents after 3 months with ageing at 500C compared with primary tobramycine were selected as a dependent variable. Experimental model was designed according to model of quadratic equation including 9 formulas. The relationship between independent variables X and dependent variables Y conformed to quadratic regressive equation. Base on preliminary formulas selected, Modde 5.0 software was used to trace experimentally and deal with the results. Optimal formula of tobramycine eye drop 0.3% had stableness over 3 months at 50oC and over 12 months at normal condition
