Prospective study on the effect of different iodine intakes on goiter and thyroid nodules
10.3760/cma.j.issn.1000-6699.2009.03.004
- VernacularTitle:不同碘摄入量对甲状腺肿和甲状腺结节影响的前瞻性研究
- Author:
Xiaohui YU
;
Chenling FAN
;
Zhongyan SHAN
;
Xiaochun TENG
;
Di TENG
;
Haixia GUAN
;
Yushu LI
;
Wei CHONG
;
Fan YANG
;
Hong DAI
;
Li HE
;
Qingjun GAO
;
Yang YU
;
Jia LI
;
Yanyan CHEN
;
Dong ZHAO
;
Jinyuan MAO
;
Xiaolan GU
;
Rong YANG
;
Yaqiu JIANG
;
Chenyang LI
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Iodine;
Goiter;
Thyroid nodules;
Epidemiological study;
Prospective study
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiological characteristics of non-toxic goiter and non-toxic thyroid nodules in the regions with different iodine intakes and the factors influencing the occurrence, development and outcome of goiter and thyroid nodules. Methods 3 385 subjects, who had taken part in the previous survey in 1999 with the ultrasonic examination of thyroid, were composed of individuals in Panshan with chronic mild iodine deficiency,in Zhangwu with more than adequate iodine "after iodine supplementation and in Huanghua with excessive iodine. These 3 groups of subjects were followed up in 2004. Results (1) The cumulative incidences of diffuse goiter in Panshan ,Zhangwu and Huanghua were 7.1% ,4.4% and 6.9% ,respectively ,being the lowest in Zhangwu (P<0.01) and those of nodular goiter were 5.0% ,2. 4% and 0.8%, respectively, being the highest in Panshan (P<0.01). (2) The incidences of single nodule were 4.0% ,5.7% and 5.6%, respectively, and those of multiple nodules 0.4%, 1.2% and 1.0%, respectively. (3)The result of logistic analysis showed that iodine deficiency,iodine excess and positive thyroid autoantibodies (TAA) were the independent risk factors for the occurrence of goiter. (4)In Zhangwu ,the incidence of non-toxic goiter in the group with positive TAA was higher than that in the group with negative TAA(P<0.01) ,while there were no such differences in Panshan and Huanghua. (5)In these three regions, the rates of positive TAA in the individuals with diffuse non-toxic goiter were higher than those in the healthy subjects (P<0.05). And in Huanghua,the rate of positive TAA in subjects with non-toxic nodular goiter was also higher than that in the healthy individuals (P<0.05). Conclusion Iodine deficiency and iodine excess may both induce the raising incidence of goiter. Nodular goiter is prevalent in iodine deficient district and diffuse goiter is the predominant form in places with iodine excess. Thyroid autoimmunity is associated with occurrence and maintenance of goiter, and this phenomenon is more obvious in the community with previous iodine deficiency followed then by treatment with more than adequate iodine.
