The role of 131Ⅰ in the apoptosis of thyrocytes of patient with Graves' disease
10.3760/cma.j.issn.1000-6699.2009.03.011
- VernacularTitle:131Ⅰ对Graves病患者甲状腺细胞凋亡的影响
- Author:
Xiaoyan FENG
;
Xianfeng LI
;
Jianzhong LIU
;
Deshan ZHAO
;
Chenggang ZHANG
;
Sijin LI
;
Ming CAI
- Publication Type:Journal Article
- Keywords:
Graves'disease;
131Ⅰ therapy;
Apoptosis;
Apoptosis-related proteins
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):280-281
- CountryChina
- Language:Chinese
-
Abstract:
The changes of Fas.FasL and Bcl-2 expression in thyrocytes of patients with Graves'disease were investigated before and 2 weeks after 131Ⅰ administration. The results showed that 131Ⅰ couhl induce thyrocytes to express the apoptotic protein Fas, FasL and the anti-apoptotic protein Bet-2 in patients with Graves'disease. A statistically significant correlation was found between the dose of 131Ⅰ and the expression levels of Fas and FasL but not Bet-2 ,suggesting that early onset of hypothyroid after 131Ⅰ administration may be due to the increased expression of Fas and FasL in thyrocytes.
