Expression of visfatin in MIN6 islet IS-cells and effects of glucose and palmitate
10.3760/cma.j.issn.1000-6699.2009.03.024
- VernacularTitle:内脂素在MIN6胰岛β细胞的表达及葡萄糖和棕榈酸对其表达的影响
- Author:
Qun CHENG
;
Yongde PENG
;
Weiping DONG
;
Yufei WANG
;
Yufan WANG
;
Xiaoying DING
- Publication Type:Journal Article
- Keywords:
Visfatin;
Glucose;
Palmitate;
Insulin secretion
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(3):318-319
- CountryChina
- Language:Chinese
-
Abstract:
Visfatin was expressed in rat anti mouse islets,as well as in MIN6 cells. The visfatin expression was affected by various concentrations of environmental glucose (5.5 and 33.3 mmoL/L) and palmitate(0.5 mmol/L). As compared with low-level glucose medium (5.5 mmol/L, 1.0±0.11) , visfatin expression increased in media with high glucose and palmitate (1.32 ±0. 18, 1. 33±0. 15,1.72±0.27, all P<0. 05). The result suggests that visfatin seems to be involved in the regulation of insulin secretion.
